The name that is transliterated as “Isaac” in English is signed in Spanish Sign Language and French Sign Language with a sign that is linked to his mother’s laughter when she hears that she will be pregnant with him (referring to Genesis 18:12 – 18:15) and also is the meaning of the Hebrew “Isaac” (Yitschaq — “he laughs”):

“Isaac” in French Sign Language (source: La Bible en langue des signes française )