Exegesis:

phonēsas phōnē megalē ‘calling out with a loud voice,’ going with eipen, not referring to a separate act.

eis cheiras sou paratithemai to pneuma mou lit. ‘into your hands I place my spirit’ (cf. Ps. 31.6 LXX). The phrase ‘to place into the hands of (somebody)’ has here the connotation of ‘giving over,’ ‘commending,’ ‘entrusting.’ For to pneuma in the anthropological sense of the word cf. on 1.47.

exepneusen lit. ‘he breathed out,’ hence, ‘he expired,’ ‘he died.’

Translation:

Crying with a loud voice, cf. on 4.33.

Spirit, cf. on 1.47; more often than not the term to be used is different from the one rendering ‘(Holy) Spirit.’

He breathed his last, or, ‘he died’ (e.g. in Kituba, Trukese). Equivalent idioms are, ‘his life-force broke-off’ (Bahasa Indonesia, Balinese), ‘his breath stopped, or, was-exhausted’ (Ekari, Sranan Tongo; Tae’ 1933), ‘his breath (and body) parted-with-each-other’ (Toraja-Sa’dan).

Quoted with permission from Reiling, J. and Swellengrebel, J.L. A Handbook on the Gospel of Luke. (UBS Handbook Series). New York: UBS, 1971. For this and other handbooks for translators see here . Make sure to also consult the Handbook on the Gospel of Mark for parallel or similar verses.